An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results
نویسندگان
چکیده
Advanced cutaneous squamous cell carcinoma (cSCC) can be a life-threatening disease for which effective and safe treatment in advanced stages is very limited. GP-2250 has been recently proven to have—in vitro vivo—antineoplastic effects on cancer cells. This study aims investigate the potential anti-neoplastic of cSCC lines SCC13 A431 through dose finding assessments, MTT cytotoxicity assays, migration BrdU proliferation assays FCM analysis. Our preliminary results have shown first time evidence cells, enhancing cytotoxicity, attenuating proliferation, inducing apoptosis reducing tumour migration. Further investigations evaluating modes action are warranted order justify use vivo studies.
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ژورنال
عنوان ژورنال: Dermato
سال: 2023
ISSN: ['2673-6179']
DOI: https://doi.org/10.3390/dermato3010007